Sodium Nitroprusside for Advanced Low-Output Heart Failure

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Sodium nitroprusside for advanced low-output heart failure.

OBJECTIVES This study was designed to examine the safety and efficacy of sodium nitroprusside (SNP) for patients with acute decompensated heart failure (ADHF) and low-output states. BACKGROUND Inotropic therapy has been predominantly used in the management of patients with ADHF presenting with low cardiac output. METHODS We reviewed all consecutive patients with ADHF admitted between 2000 a...

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Comparative responses to dobutamine and nitroprusside in patients with chronic low output cardiac failure.

The acute hemodynamic effects of dobutamine and nitroprusside were compared in 19 patients with low output cardiac failure. At dosage levels yielding similar increases in cardiac index (12 patients), nitroprusside resulted in significantly lower arterial systolic and wedge pressures and did not increase heart rate suggesting advantages over dobutamine when reduction in myocardial oxygen require...

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The symptoms and signs of heart failure can occur in the setting of an increased cardiac output and has been termed 'high output heart failure'. An elevated cardiac output with clinical heart failure is associated with several diseases including chronic anaemia, systemic arterio-venous fistulae, sepsis, hypercapnia and hyperthyroidism. The underlying primary physiological problem is of reduced ...

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Predictors of low cardiac output in decompensated severe heart failure

OBJECTIVE To identify predictors of low cardiac output and mortality in decompensated heart failure. INTRODUCTION Introduction: Patients with decompensated heart failure have a high mortality rate, especially those patients with low cardiac output. However, this clinical presentation is uncommon, and its management is controversial. METHODS We studied a cohort of 452 patients hospitalized w...

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Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2008

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2008.02.083